2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-103188
    PD81723 132861-87-1 99.63%
    PD81723 is an adenosine receptor binding enhancer. PD81723 enhances the inhibition of exogenous adenosine in a dose-dependent manner in hippocampal brain sections.
    PD81723
  • HY-103201
    A 80426 mesylate 152148-64-6 98%
    A 80426 mesylate is an α2-adrenoceptor antagonist. A 80426 mesylate is used in antidepressant research.
    A 80426 mesylate
  • HY-103339
    VDM11 313998-81-1 99.25%
    VDM11 is a potent and selective anandamide membrane transporter (AMT) inhibitor. VDM11 inhibits FAAH and MAGL and may act as an alternative FAAH substrate.
    VDM11
  • HY-103375
    SN003 197801-88-0 98%
    SN003 is a reversible antagonist of corticotropin releasing factor receptor 1 (CRFR 1) (IC50 = 241 nM) that displays more than 1000-fold selectivity over CRFR 2. SN003 suppresses CRF-induced ACTH release in vitro. SN003 attenuates depressive-like behavior in rat.
    SN003
  • HY-10349R
    WAY-100635 (Standard) 162760-96-5 98%
    WAY-100635 (Standard) is the analytical standard of WAY-100635. This product is intended for research and analytical applications. WAY-100635 is a potent and selective 5-HT1A Receptor antagonist with a pIC50 of 8.87, an apparent pA2 of 9.71. WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 is also a potent dopamine D4 receptor agonist.
    WAY-100635 (Standard)
  • HY-103535
    GBLD345 122479-08-7 98%
    GBLD345, a nonbenzodiazepine anxiolytic agent, is a non- selective, potent GABAA receptor positive allosteric modulator (PAM).
    GBLD345
  • HY-10388R
    TTA-Q6 (Standard) 910484-28-5
    TTA-Q6 (Standard) is the analytical standard of TTA-Q6 (HY-10388). This product is intended for research and analytical applications. TTA-Q6 is a selective T-type Ca2+ channel antagonist, which can be used in the research of neurological disease.
    TTA-Q6 (Standard)
  • HY-10396R
    Emricasan (Standard) 254750-02-2 98%
    Emricasan (Standard) is the analytical standard of Emricasan. This product is intended for research and analytical applications. Emricasan (PF 03491390) is an orally active and irreversible pan-caspase inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors.
    Emricasan (Standard)
  • HY-10399B
    (S)-Ladostigil 209394-29-6 98%
    (S)-Ladostigil (TV-3279), the S-enantiomer of TV 3326 (HY-10399), is a ChE inhibitor with poor MAO-B inhibitory activity. (S)-Ladostigil has neuroprotective effect
    (S)-Ladostigil
  • HY-10400R
    Ladostigil hemitartrate (Standard) 209394-46-7 98%
    Ladostigil hemitartrate (Standard) is the analytical standard of Ladostigil hemitartrate (HY-10400). This product is intended for research and analytical applications. Ladostigil (TV-3326) hemitartrate is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hemitartrate exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil hemitartrate can be used for the research of depression and Alzheimer's disease. Ladostigil hemitartrate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Ladostigil hemitartrate (Standard)
  • HY-10406R
    Talmapimod (Standard) 309913-83-5 98%
    Talmapimod (Standard) is the analytical standard of Talmapimod (HY-10406). This product is intended for research and analytical applications. Talmapimod (SCIO-469) is an orally active and selective inhibitor of p38α MAPK with an IC50 of 9 nM. Talmapimod inhibits the secretion of inflammatory factors (such as TNFα, IL-1β, IL-6, and VEGF) by suppressing the p38α MAPK pathway, and it also inhibits angiogenesis and osteoclast activation. Talmapimod inhibits the growth of multiple myeloma cells and induces apoptosis. Talmapimod can be used to study various hematological malignancies (such as multiple myeloma, myelodysplastic syndrome).
    Talmapimod (Standard)
  • HY-10457R
    Velusetrag (Standard) 866933-46-2 98%
    Velusetrag (Standard) is the analytical standard of Velusetrag (HY-10457). This product is intended for research and analytical applications. Velusetrag (TD-5108) is an orally active, potent and selective agonist of serotonin 5-HT4 receptor (5-HT4R), with a pKi of 7.7. Velusetrag exhibits no affinity (Ki>10 μM) for 5-HT2A and 5-HT2B receptors. Velusetrag can be used for the research of gastrointestinal diseases and Parkinson's disease.
    Velusetrag (Standard)
  • HY-10472R
    LY2811376 (Standard) 1194044-20-6
    LY2811376 (Standard) is the analytical standard of LY2811376 (HY-10472). This product is intended for research and analytical applications. LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.
    LY2811376 (Standard)
  • HY-10487R
    JDTic dihydrochloride (Standard) 785835-79-2
    JDTic dihydrochloride (Standard) is the analytical standard of JDTic dihydrochloride (HY-10487). This product is intended for research and analytical applications. JDTic dihydrochloride is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.
    JDTic dihydrochloride (Standard)
  • HY-10499R
    PH-064 (Standard) 892546-37-1
    PH-064 (Standard) is the analytical standard of PH-064 (HY-10499). This product is intended for research and analytical applications. PH-064 (BIM-46187) is an orally active inhibitor of the heterotrimeric G-protein complex. PH-064 inhibits SERT activity and attenuates shear stress-induced Akt phosphorylation. PH-064 has potent anti-hyperalgesia activity. PH-064 inhibits G protein-coupled receptor-dependent tumorigenesis. PH-064 can be used in the study of pain (e.g., inflammatory pain, neuropathic pain), GPCR-dependent tumors, and inflammatory lung injury.
    PH-064 (Standard)
  • HY-105034
    Tiospirone 87691-91-6 98%
    Tiospirone is a 5-HT2 receptor antagonist with affinity for D2, 5-HT1a, and 5-HT7, and sigma receptors. Tiospirone decreases consumption of ethanol while increasing food intake of rats. Tiospirone can also reduce the reinforcing properties of Cocaine exhibited in the conditioned place preference paradigm.
    Tiospirone
  • HY-105108
    Cilansetron hydrochloride hydrate 209859-87-0 98%
    Cilansetron hydrochloride hydrate is a 5-HT3 receptor antagonist. Cilansetron hydrochloride hydrate can be used in studies of irritable bowel syndrome.
    Cilansetron hydrochloride hydrate
  • HY-105109
    Cilansetron 120635-74-7 99.98%
    Cilansetron is a 5-HT3 receptor antagonist. Cilansetron can be used in studies of irritable bowel syndrome.
    Cilansetron
  • HY-105127
    Brofaromine hydrochloride 63638-90-4 98%
    Brofaromine (hydrochloride) is a monoamine oxidase A (MAO-A) inhibitor and a 5-HT uptake inhibitor. Brofaromine (hydrochloride) shows antidepressant-like activity in the social conflict test in rats.
    Brofaromine hydrochloride
  • HY-105132
    Binodaline 60662-16-0 98%
    Binodaline is a selective norepinephrine reuptake inhibitor with a Ki of 25 nM. Binodaline can be used in the study of depressive disorder.
    Binodaline
Cat. No. Product Name / Synonyms Application Reactivity